Saturday, August 13, 2011

Methanol, ethylene. Enzyme and etanol.?

Methanol (wood alcohol) and ethylene glycol (antifreeze) are poisonous when ingested. These substances compete with ethanol (the alcohol found in wine, beer, and spirits) for the active site on the enzyme, alcohol dehydrogenase. Alcohol dehydrogenase breaks ethylene glycol (and methanol) down into very toxic substances, which can lead to metabolic acidosis and death. The kidneys are capable of getting rid of ethylene glycol and methanol without harm if the alcohol dehydrogenase does not break them down. The treatment for ethylene glycol or methanol poisoning involves intravenous administration of ethanol. You get the patient drunk! Why would this therapy be appropriate

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